Muscle contraction: Quick-frozen crossbridges
نویسندگان
چکیده
منابع مشابه
Theory of muscle contraction mechanism with cooperative interaction among crossbridges
The power stroke model was criticized and a model was proposed for muscle contraction mechanism (Mitsui, 1999). The proposed model was further developed and calculations based on the model well reproduced major experimental data on the steady filament sliding (Mitsui and Ohshima, 2008) and on the transient phenomena (Mitsui, Takai and Ohshima, 2011). In this review more weight is put on explana...
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Motor actions of myosin were directly visualized by electron tomography of insect flight muscle quick-frozen during contraction. In 3D images, active cross-bridges are usually single myosin heads, bound preferentially to actin target zones sited midway between troponins. Active attached bridges (approximately 30% of all heads) depart markedly in axial and azimuthal angles from Rayment's rigor a...
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angle of the MD and/or the LCD lever arm have not been Max-Planck-Institut fü r Medizinische Forschung directly visualized in 3D in active muscle. Abteilung Biophysik Visualizing crossbridges during force development, 29 Jahnstrasse including those bound to actin in the weak binding states D69120 Heidelberg thought to precede force production, is critical for defin-Germany ing the structural tr...
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Detrusor smooth muscle exhibits myogenic contraction in response to a quick stretch (QS) as well as spontaneous rhythmic contraction (SRC); however, whether the same population of actomyosin crossbridges with a common regulatory mechanism is responsible for these two types of contraction has not been determined. Detrusor strips from New Zealand white rabbit bladders were allowed to develop SRC ...
متن کاملStructural changes in muscle crossbridges accompanying force generation
We have investigated the structure of the crossbridges in muscles rapidly frozen while relaxed, in rigor, and at various times after activation from rigor by flash photolysis of caged ATP. We used Fourier analysis of images of cross sections to obtain an average view of the muscle structure, and correspondence analysis to extract information about individual crossbridge shapes. The crossbridge ...
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ژورنال
عنوان ژورنال: Nature
سال: 1985
ISSN: 0028-0836,1476-4687
DOI: 10.1038/317113a0